| December 31, 2021 | “Spider-Man: No Way Home” | $56,023,590 | SON |
| December 24, 2021 | “Spider-Man: No Way Home” | $84,548,505 | SON |
| December 17, 2021 | “Spider-Man: No Way Home” | $260,138,569 | SON |
| December 10, 2021 | “West Side Story” | $10,574,618 | 20TH |
| December 3, 2021 | “Encanto” | $13,147,618 | DIS |
| November 26, 2021 | “Encanto” | $27,206,494 | DIS |
| November 19, 2021 | “Ghostbusters: Afterlife” | $44,008,406 | SON |
| November 12, 2021 | “Eternals” | $26,850,128 | DIS |
| November 5, 2021 | “Eternals” | $71,297,219 | DIS |
| October 29, 2021 | “Dune” | $15,413,486 | WB |
| October 22, 2021 | “Dune” | $41,011,174 | WB |
| October 15, 2021 | “Halloween Kills” | $49,404,980 | UNI |
| October 8, 2021 | “No Time To Die” | $55,225,007 | MGM |
| October 1, 2021 | “Venom: Let There Be Carnage” | $90,033,210 | SON |
| September 24, 2021 | “Shang-Chi and the Legend of the Ten Rings” | $13,031,411 | DIS |
| September 17, 2021 | “Shang-Chi and the Legend of the Ten Rings” | $21,670,751 | DIS |
| September 10, 2021 | “Shang-Chi and the Legend of the Ten Rings” | $34,701,070 | DIS |
| September 3, 2021 | “Shang-Chi and the Legend of the Ten Rings” | $75,388,688 | DIS |
| August 27, 2021 | “Candyman” | $22,001,750 | UNI |
| August 20, 2021 | “Free Guy” | $18,504,022 | 20TH |
| August 13, 2021 | “Free Guy” | $28,365,416 | 20TH |
| August 6, 2021 | “The Suicide Squad” | $26,250,000 | WB |
| July 30, 2021 | “Jungle Cruise” | $35,018,731 | DIS |
| July 23, 2021 | “Old” | $16,854,735 | UNI |
| July 16, 2021 | “Space Jam: A New Legacy” | $31,053,362 | WB |
| July 9, 2021 | “Black Widow” | $80,366,312 | DIS |
| July 2, 2021 | “F9: The Fast Saga” | $23,008,860 | UNI |
| June 25, 2021 | “F9: The Fast Saga” | $70,043,165 | UNI |
| June 18, 2021 | “The Hitman’s Wife’s Bodyguard” | $11,397,820 | LG |
| June 11, 2021 | “A Quiet Place Part II” | $12,012,263 | PAR |
| June 4, 2021 | “The Conjuring: The Devil Made Me Do It” | $24,104,332 | WB |
| May 28, 2021 | “A Quiet Place Part II” | $47,547,231 | PAR |
| May 21, 2021 | “Spiral” | $4,595,320 | LG |
| May 14, 2021 | “Spiral” | $8,750,034 | LG |
| May 7, 2021 | “Wrath of Man” | $8,309,007 | MGM |
| April 30, 2021 | “Demon Slayer: Mugen Train” | $6,412,933 | FUN |
| April 23, 2021 | “Mortal Kombat” | $23,302,503 | WB |
| April 16, 2021 | “Godzilla vs. Kong” | $7,847,227 | WB |
| April 9, 2021 | “Godzilla vs. Kong” | $13,882,474 | WB |
| April 2, 2021 | “Godzilla vs. Kong” | $31,625,971 | WB |
| March 26, 2021 | “Nobody” | $6,820,100 | UNI |
| March 19, 2021 | “Raya and the Last Dragon” | $5,129,473 | DIS |
| March 12, 2021 | “Raya and the Last Dragon” | $5,706,633 | DIS |
| March 5, 2021 | “Raya and the Last Dragon” | $8,502,498 | DIS |
| February 26, 2021 | “Tom and Jerry” | $14,110,000 | WB |
| February 19, 2021 | “The Croods: A New Age” | $1,718,455 | UNI |
| February 12, 2021 | “The Croods: A New Age” | $2,079,825 | UNI |
| February 5, 2021 | “The Little Things” | $2,100,000 | WB |
| January 29, 2021 | “The Little Things” | $4,700,000 | WB |
| January 22, 2021 | “The Marksman” | $2,000,000 | OR |
| January 15, 2021 | “The Marksman” | $3,104,204 | OR |
| January 8, 2021 | “Wonder Woman 1984” | $3,000,000 | WB |
| January 1, 2021 | “Wonder Woman 1984” | $5,500,000 | WB |
